Capture Hi-C identifies putative target genes at 33 breast cancer risk loci
نویسندگان
چکیده
منابع مشابه
Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci
Multiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide agnostic characterization of chromatin contacts. However, detection of functional enhancer-promoter interactions is precluded by its effective resolution that is determined...
متن کاملCapture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci.
Genome-wide association studies have been tremendously successful in identifying genetic variants associated with complex diseases. The majority of association signals are intergenic and evidence is accumulating that a high proportion of signals lie in enhancer regions. We use Capture Hi-C to investigate, for the first time, the interactions between associated variants for four autoimmune disea...
متن کاملA multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24.
BACKGROUND Heritable risk for breast cancer includes an increasing number of common, low effect risk variants. We conducted a multistage genetic association study in a series of independent epidemiologic breast cancer study populations to identify novel breast cancer risk variants. METHODS We tested 1,162 SNPs of greatest nominal significance from stage I of the Cancer Genetic Markers of Susc...
متن کاملIdentifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C
BACKGROUND The chromosomal region 6q23 has been found to be associated with multiple sclerosis (MS) predisposition through genome wide association studies (GWAS). There are four independent single nucleotide polymorphisms (SNPs) associated with MS in this region, which spans around 2.5 Mb. Most GWAS variants associated with complex traits, including these four MS associated SNPs, are non-coding...
متن کاملHi-C: Genome-wide Chromosome Conformation Capture
The three-dimensional conformation of chromosomes in the nucleus is important for many cellular processes, including the regulation of gene expression, DNA replication, and chromatin structure [1]. Despite having the entire sequence of the genome, very little has been understood about three-dimensional chromosome conformation beyond the scale of the nucleosome. However, recent advances in molec...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-03411-9